What Is Causing My Low Testosterone? | Moorgate Andrology

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What Is Causing My Low Testosterone?

low testosterone

Low Testosterone Prevalence

Low testosterone affects 4 to 5 million men across the globe. Testosterone is an important hormone in the human body. But it starts to decrease each year after age 30. In some men, this can be substantial. Between 19 and 39%of older men may have low levels of testosterone.

Older men with low testosterone have increasingly sought testosterone replacement therapy in recent years. TRT addresses symptoms such as low libido, poor muscle mass, and low energy. It is not just older men that are affected by low testosterone. Young men, even babies and children can also have this problem.


Symptoms of Low Testosterone

Low levels of testosterone that are typical of normal ageing are due to other primary or secondary causes of hypogonadism. Hypogonadism in males happens when the testicles do not produce enough testosterone. Hypogonadism can start during fetal development, during puberty, or during adulthood.

Fetal Development

If hypogonadism begins during fetal development, the primary result is impaired growth of external sex organs. Depending on when hypogonadism starts and the level of testosterone present during fetal development, a male child can develop

  • Female genitals
  • Ambiguous genitals, neither clearly male or female
  • Underdeveloped male genitals



Normal growth can be jeopardized if hypogonadism occurs during puberty. Problems occur with:

  • Muscle development
  • Deepening of the voice
  • Lack of body hair
  • Underdeveloped genitals
  • Overly long limbs
  • Enlarged breasts



Later in life, insufficient testosterone can lead to other problems. Symptoms include:

Fatigue and mental fogginess are some commonly reported mental and emotional symptoms in men with low testosterone.


Primary Hypogonadism

Underactive testes cause primary hypogonadism. That is because they do not manufacture sufficient levels of testosterone for optimal growth and health. This interactivity can be caused by an inherited trait. It can also be acquired by accident or illness. Inherited conditions include:


  • Undescended testicles: When the testicles fail to descend from the abdomen before birth
  • Klinefelter’s syndrome: A condition in which a man is born with three sex chromosomes: X, X and Y.
  • Hemochromatosis: Too much iron in the blood causes testicular failure or pituitary damage.


Types of testicle damage that can lead to primary hypogonadism include:


  • Physical Injury to the Testicles: Injury must occur to both testicles to affect testosterone levels.
  • Mumps Orchitis: Mumps infection can injure testicles.
  • Cancer Treatment: Chemotherapy or radiation can damage testicles.



Secondary Hypogonadism

Secondary hypogonadism is caused by damage to the pituitary gland or hypothalamus. These parts of the brain control hormone production by the testes. Inherited or disease conditions in this category include: 


  • Pituitary disorders: caused by drugs, kidney failure, or small tumours
  • Kallmann syndrome: a condition connected to abnormal hypothalamus function
  • Inflammatory diseases: Such as tuberculosis, sarcoidosis, and histiocytosis, which can impact the pituitary gland and the hypothalamus. 


Acquired circumstances that can lead to secondary hypogonadism include:



  • Normal ageing: Aging affects production and response to hormones.
  • Obesity: High body fat can affect hormone production and response.
  • Medications: Opioid pain meds and steroids can affect the function of the pituitary gland and hypothalamus.
  • Concurrent Illness: Severe emotional stress or physical stress from an illness or surgery can cause the reproductive system to temporarily shut down.



You may be affected by primary, secondary, or mixed hypogonadism. Mixed hypogonadism is more common with increased age. People undergoing glucocorticoid therapy can develop the condition. It also can affect people with sickle cell disease, thalassemia, or alcoholism.

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